Forschungsschwerpunkt Translationale Neurowissenschaften Mainz

Resilience

Research Group “Resilience”

Please follow this link to find more information concerning the “Mainz Resilience Project“ (MARP).

Resilience is the process of maintaining or regaining one’s mental health during or after severely stressful life stituations. Traditionally, psychiatric research has focused on mechanisms that make people vulnerable and lead to disease and on ways of treating mental illness. Interestingly, however, many people do not or only temporarily become mentally ill despite significant burden from psychological or physical adversity. This suggests the existence of protective mechanisms that can prevent the development of stress-related conditions like anxiety, post-traumatic stress, depression or addiction. Our approach is to understand these resilience mechanisms and to harness them in the service of better disease prevention. This strategy can potentially much reduce individual suffering, dysfunction and economic and social costs.

Protective mechanisms that currently are in the focus of our research are fear extinction and cognitive emotion regulation (e.g. reappraisal).

Members of the research group “Resilience”:

Group leader: Prof. Dr. R. Kalisch
Members: Kenneth S.L. Yuen, PhD (scientist)
Benjamin Meyer, Dr. rer.nat., Dipl.-Biol. (scientist)
Anita Schick, Dr. sc. hum, Dipl.-Psych. (scientist)
Anna Gerlicher, MSc (PhD student)
Miriam Kampa, Dipl.-Psych. (PhD student)
Martina Thiele, MSc (PhD student)
Petra Seyfarth (MTA-R)
Julian Behr (MD student, research assistant)
Manuela Götz (student research assistant)
Anna Katharina Müller(student research assistant)
Johannes Plesch (student research asssistant)
Victor Saase (MD student, research assistant)
Merle Wachendörfer (student research asssistant)
Vanessa Zörrer(student research asssistant)

 

NIC_Resilience

Key publications

Meyer B, Yuen KS, Ertl M, Polomac N, Mulert C, Büchel C, Kalisch R.(2015). Neural mechanisms of placebo anxiolysis. J Neurosci., 35(19):7365-73. doi: 10.1523/JNEUROSCI.4793-14.2015.

Kalisch, R., Müller, M. B., & Tüscher, O. (2015). Advancing empirical resilience research. The Behavioral and Brain Sciences, 38:e128. doi: 10.1017/S0140525X15000023.

Kalisch, R., Müller, M. B., & Tüscher, O. (2015). A conceptual framework for the neurobiological study of resilience. The Behavioral and Brain Sciences, 38:e92. doi: 10.1017/S0140525X1400082X. Epub 2014 Aug 27..

Kalisch R, Gerlicher A (2014). Making a mountain out of a molehill: On the role of the rostral dorsal anterior cingulate and dorsomedial prefrontal cortex in conscious threat appraisal, catastrophizing, and worrying. Neurosci Biobehav Rev. Feb 10; 42C: 1-8. doi: 10.1016

Haaker J, Gaburro S, Sah A, Gartmann N, Lonsdorf TB, Meier K, Singewald N, Pape HC, Morellini F*, Kalisch R* (2013) Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear. PNAS 110:E2428-36. * equal contribution

Etkin A, Egner T, Kalisch R (2011) Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 15:85-93.

Raczka KA, Mechias ML, Gartmann N, Reif A, Deckert J, PessiglioneM, Kalisch R (2011). Empirical support for an involvement of the mesostriatal dopamine system in human fear extinction. Transl Psychiatry 1, e12, doi:10.1038/tp.2011.10

Raczka KA, Gartmann N, Mechias ML, Reif A, Büchel C, Deckert J, Kalisch R (2010). A neuropeptide S receptor variant associated with over-interpretation of fear reactions: a potential neurogenetic basis for catastrophizing. Mol Psychiatry; 15: 1067-74. Corrigendum: 17(4):468.

Kalisch R (2009). The functional neuroanatomy of reappraisal: time matters. Neurosci Biobehav Rev 33:1215-26.

Kalisch R, Korenfeld E, Stephan KE, Weiskopf N, Seymour B, Dolan RJ (2006). Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network.J Neurosci. Sep 13; 26(37): 9503-11.

News

14. September 2017
NIC meeting
Christian Paret (Central Institute of Mental Health, Mannheim) will give a talk on “Real-time fMRI neurofeedback from the amygdala: Feasibility, clinical application and brain mechanisms” in the NIC meeting on Thursday, September 14th....more
24. August 2017
NIC meeting
Dr. Til Ole Bergmann (University of Tübingen) will be guest speaker in the NIC meeting on Thursday, August 24th. His talk: “On the function of neuronal oscillations – insights from transcranial brain stimulation and multimodal imaging” will be at noon in the seminar room in building 701....more
13. July 2017
NIC meeting
Philipp Horstmann (Psychiatry, Mainz) will present the current status of the MRI study investigating the influence of prg-1 (plasticity related gene) genotype on brain morphology and function in the NIC meeting on July 13th. The NIC meetings starts at 12:00 in the seminar room in building 701!...more