Forschungsschwerpunkt Translationale Neurowissenschaften Mainz


Research group „Emotion Regulation and Impulse Control (ERIC)“

Emotional dysregulation and impaired impulse control (impulsivity) are central components of several disorders (e.g. Attention Deficit / Hyperactivity Syndrome (ADHD), Borderline Personality Disorder (BPD), substance dependence, Parkinson’s syndrome). Hence, our research focus is emotion regulation and emotion processing as well as impulse control in healthy subjects and their alterations in disorders in which dysfunctions in these domains often occur. The overall goal is a systematic investigation of cognitive phenotypes to develop translationally assessable cognitive endophenotypes. Therefore, we use in conjunction with behavioral experiments a broad spectrum of imaging methods such as functional magnetic resonance imaging (fMRI), simultaneous EEG-fMRI, magnetic encephalography (MEG) as well as imaging genetics.


Head of group:

PD Dr. med. habil. Oliver Tüscher


Team members:

Dr. med. Patrick Jung

cand. med. Jonathan Neuhoff

Dr. med. Philippe Pfeifer

Dipl.-Psych. Neele Reiss

Dipl.-Biol. Lena Schmüser

Dipl.-Psych. Cornelia Schwarze

Dipl.-Psych. Alexandra Sebastian

Dipl.-Psych. Jutta Stoffers


Selected publications:

Jacob GA, Zvonik K, Kamphausen S, Sebastian A, Maier S, Philipsen A, van Tebartz Elst L, Lieb K, Tüscher O (2012). Emotional Modulation of Motor Response Inhibition in Women with Borderline Personality Disorder – a functional MRI Study: Journal of Psychiatry and Neuroscience, 37(6):120029. doi: 10.1503/jpn.120029. [Epub ahead of print]

Jung P, Klein JC, Wibral M, Hoechstetter K, Bliem B, Lu MK, Wahl M, Ziemann U (2012). Spatiotemporal dynamics of bimanual integration in human somatosensory cortex and their relevance to bimanual object manipulation. J Neurosci, 32(16), 5667-77.

Jung P & Ziemann U (2009). Homeostatic and Nonhomeostatic Modulation of Learning in Human Motor Cortex. J Neurosci, 29(17), 5597-5604.

Kamphausen S, Schröder P, Maier S, Bader K, Feige B, Kaller CP, Glauche V, Ohlendorf S, Elst LT, Klöppel S, Jacob GA, Silbersweig D, Lieb K, Tüscher O (2012). Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. World J Biol Psychiatry. [Epub ahead of print]

Sebastian A, Pohl MF, Klöppel S, Feige B, Lange T, Stahl C, Voss A, Klauer KC, Lieb K, Tüscher O (2013). Disentangling common and specific neural subprocesses of response inhibition. Neuroimage, 64, 601-615.

Sebastian A, Gerdes B, Feige B, Klöppel S, Lange T, Philipsen A, Tebartz van Elst L, Lieb K, Tüscher O (2012). Neural correlates of interference inhibition, action withholding and action cancelation in adult ADHD. Psychiatry Res, 202(2), 132-141.

Warbrick T, Mobascher A, Brinkmeyer J, Musso F, Stoecker T, Shah NJ, Fink GR, Winterer G (2012). Nicotine effects on brain function during a visual oddball task: a comparison between conventional and EEG-informed fMRI analysis. J Cogn Neurosci, 24(8), 1682-94.

Quednow BB, Brinkmeyer J, Mobascher A, Nothnagel M, Musso F, Gründer G, Savary N, Petrovsky N, Frommann I, Lennertz L, Spreckelmeyer KN, Wienker TF, Dahmen N, Thuerauf N, Clepce M, Kiefer F, Majic T, Mössner R, Maier W, Gallinat J, Diaz-Lacava A, Toliat MR, Thiele H, Nürnberg P, Wagner M, Winterer G (2012). Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating. Proc Natl Acad Sci USA, 109(16), 6271-6276.


14. September 2017
NIC meeting
Christian Paret (Central Institute of Mental Health, Mannheim) will give a talk on “Real-time fMRI neurofeedback from the amygdala: Feasibility, clinical application and brain mechanisms” in the NIC meeting on Thursday, September 14th....more
24. August 2017
NIC meeting
Dr. Til Ole Bergmann (University of Tübingen) will be guest speaker in the NIC meeting on Thursday, August 24th. His talk: “On the function of neuronal oscillations – insights from transcranial brain stimulation and multimodal imaging” will be at noon in the seminar room in building 701....more
13. July 2017
NIC meeting
Philipp Horstmann (Psychiatry, Mainz) will present the current status of the MRI study investigating the influence of prg-1 (plasticity related gene) genotype on brain morphology and function in the NIC meeting on July 13th. The NIC meetings starts at 12:00 in the seminar room in building 701!...more