Forschungsschwerpunkt Translationale Neurowissenschaften Mainz

ERIC

Research group „Emotion Regulation and Impulse Control (ERIC)“

Emotional dysregulation and impaired impulse control (impulsivity) are central components of several disorders (e.g. Attention Deficit / Hyperactivity Syndrome (ADHD), Borderline Personality Disorder (BPD), substance dependence, Parkinson’s syndrome). Hence, our research focus is emotion regulation and emotion processing as well as impulse control in healthy subjects and their alterations in disorders in which dysfunctions in these domains often occur. The overall goal is a systematic investigation of cognitive phenotypes to develop translationally assessable cognitive endophenotypes. Therefore, we use in conjunction with behavioral experiments a broad spectrum of imaging methods such as functional magnetic resonance imaging (fMRI), simultaneous EEG-fMRI, magnetic encephalography (MEG) as well as imaging genetics.

 

Head of group:

PD Dr. med. habil. Oliver Tüscher

 

Team members:

Dr. med. Patrick Jung

cand. med. Jonathan Neuhoff

Dr. med. Philippe Pfeifer

Dipl.-Psych. Neele Reiss

Dipl.-Biol. Lena Schmüser

Dipl.-Psych. Cornelia Schwarze

Dipl.-Psych. Alexandra Sebastian

Dipl.-Psych. Jutta Stoffers

 

Selected publications:

Jacob GA, Zvonik K, Kamphausen S, Sebastian A, Maier S, Philipsen A, van Tebartz Elst L, Lieb K, Tüscher O (2012). Emotional Modulation of Motor Response Inhibition in Women with Borderline Personality Disorder – a functional MRI Study: Journal of Psychiatry and Neuroscience, 37(6):120029. doi: 10.1503/jpn.120029. [Epub ahead of print]

Jung P, Klein JC, Wibral M, Hoechstetter K, Bliem B, Lu MK, Wahl M, Ziemann U (2012). Spatiotemporal dynamics of bimanual integration in human somatosensory cortex and their relevance to bimanual object manipulation. J Neurosci, 32(16), 5667-77.

Jung P & Ziemann U (2009). Homeostatic and Nonhomeostatic Modulation of Learning in Human Motor Cortex. J Neurosci, 29(17), 5597-5604.

Kamphausen S, Schröder P, Maier S, Bader K, Feige B, Kaller CP, Glauche V, Ohlendorf S, Elst LT, Klöppel S, Jacob GA, Silbersweig D, Lieb K, Tüscher O (2012). Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. World J Biol Psychiatry. [Epub ahead of print]

Sebastian A, Pohl MF, Klöppel S, Feige B, Lange T, Stahl C, Voss A, Klauer KC, Lieb K, Tüscher O (2013). Disentangling common and specific neural subprocesses of response inhibition. Neuroimage, 64, 601-615.

Sebastian A, Gerdes B, Feige B, Klöppel S, Lange T, Philipsen A, Tebartz van Elst L, Lieb K, Tüscher O (2012). Neural correlates of interference inhibition, action withholding and action cancelation in adult ADHD. Psychiatry Res, 202(2), 132-141.

Warbrick T, Mobascher A, Brinkmeyer J, Musso F, Stoecker T, Shah NJ, Fink GR, Winterer G (2012). Nicotine effects on brain function during a visual oddball task: a comparison between conventional and EEG-informed fMRI analysis. J Cogn Neurosci, 24(8), 1682-94.

Quednow BB, Brinkmeyer J, Mobascher A, Nothnagel M, Musso F, Gründer G, Savary N, Petrovsky N, Frommann I, Lennertz L, Spreckelmeyer KN, Wienker TF, Dahmen N, Thuerauf N, Clepce M, Kiefer F, Majic T, Mössner R, Maier W, Gallinat J, Diaz-Lacava A, Toliat MR, Thiele H, Nürnberg P, Wagner M, Winterer G (2012). Schizophrenia risk polymorphisms in the TCF4 gene interact with smoking in the modulation of auditory sensory gating. Proc Natl Acad Sci USA, 109(16), 6271-6276.

News

02. November 2017
NIC meeting
Renee Visser (University Camebridge) presents her work on “Imaging the dynamic nature of emotional memory” in the NIC meeting on Thursday, November 2nd at 12am. ...more
19. October 2017
NIC meeting
Benjamin Meyer (NIC) will present his new study investigating  “The neural networks of instructed fear” in the NIC meeting on Thursday, October 19th at 12 in the seminar room....more
14. September 2017
NIC meeting
Christian Paret (Central Institute of Mental Health, Mannheim) will give a talk on “Real-time fMRI neurofeedback from the amygdala: Feasibility, clinical application and brain mechanisms” in the NIC meeting on Thursday, September 14th....more