Forschungsschwerpunkt Translationale Neurowissenschaften Mainz

Welcome

to the Neuroimaging Center (NIC) Mainz.

 

We are a core research platform of Focus Program Translational Neuroscience Mainz (FTN) and of Johannes Gutenberg University Medical Center Mainz. We are member of the Deutsches Resilienz-Zentrum (DRZ) and of  Rhine-Main Neuroscience Network (rmn²), a strategic research alliance formed by neuroscientists in Frankfurt and Mainz.

Read here about the Mainz Resilience Project (MARP), The Gutenberg Brain Study (GBS), and the DFG Collaborative Research Center CRC TR128 on Multiple Sclerosis.

The NIC has been established in 2012 under the direction of Prof. Dr. Raffael Kalisch in order to bundle and coordinate the FTN’s research activities in the field of human neuroimaging. We provide assistance with neuroimaging to all interested parties within FTN, the University Medical Center and rmn2.

The NIC has at its disposal research-only scanning time on a 3 Tesla Siemens TIM TRIO MR scanner (12- and 32-channel head coils); equipment for peripheral stimulation, psychophysiological recordings and eye-tracking; MR-compatible 64- and 256-channel EEG, MR-compatible tDCS, and TMS; two fully equipped psychophysiological laboratories for behavioral studies; dedicated Linux and Windows servers, possibilities to access the University’s high-performance computing facility (Mogon), analysis software, and an office suite with terminals for data analysis. Services include regular methods teaching activities (NIC meetings, NIC courses), advice with study design, ethics applications, stimulus presentation, sequence selection, and data analysis; and bi-weekly discussion meetings.

The core support team consists of two MR physicists (T. Bauermann, G. Vucurevic), two imaging scientists (K. Yuen, B. Meyer), and a coordinator (A. Schick).

From 2018, the NIC will be housed in a new dedicated neuroimaging building that will harbor a new 3 Tesla MR scanner, an EEG suite, other laboratories and office space for imaging groups from the faculty and FTN

Research activities at the NIC span topics like addiction, aesthetics, ageing and dementia, body and motion perception, emotion regulation, executive function, fear and anxiety, impulse control, multiple sclerosis, pain, psychopathology, resilience to stress-related mental disorders.

Recent Publications

Droby A Yuen KS, Schänzer A, Spiwoks-Becker I, Acker T, Lienerth B, Zipp F, Deichmann R.(2016). An improved anatomical MRI technique with suppression of fixative fluid artifacts for the investigation of human postmortem brain phantoms. Magn Reson Med. doi: 10.1002/mrm.26196. [Epub ahead of print]

Droby A, Yuen KS, Muthuraman M, Reitz SC, Fleischer V, Klein J, Gracien RM, Ziemann U, Deichmann R, Zipp F, Groppa S.(2015). Changes in brain functional connectivity patterns are driven by an individual lesion in MS: a resting-state fMRI study. Brain Imaging Behav. [Epub ahead of print]

Kalisch, R., Müller, M. B., & Tüscher, O. (2015). Advancing empirical resilience research. The Behavioral and Brain Sciences, 38:e128. doi: 10.1017/S0140525X15000023.

Kalisch, R., Müller, M. B., & Tüscher, O. (2015). A conceptual framework for the neurobiological study of resilience. The Behavioral and Brain Sciences, 38:e92. doi: 10.1017/S0140525X1400082X. Epub 2014 Aug 27.

Wessa M, Lois G. Brain Functional Effects of Psychopharmacological Treatment in Major Depression: a Focus on Neural Circuitry of Affective Processing. Curr Neuropharmacol. 2015;13(4):466-79.

Wilting J, Rolfsnes HO, Zimmermann H, Behrens M, Fleischer V, Zipp F, Gröger A. Structural correlates for fatigue in early relapsing remitting multiple sclerosis. Eur Radiol. 2015 May 31. [Epub ahead of print]

Droby A, Lukas C, Schänzer A, Spiwoks-Becker I, Giorgio A, Gold R, De Stefano N, Kugel H, Deppe M, Wiendl H, Meuth SG, Acker T, Zipp F, Deichmann R. A human post-mortem brain model for the standardization of multi-centre MRI studies. Neuroimage. 2015 Apr 15;110:11-21. doi: 10.1016/j.neuroimage.2015.01.028. Epub 2015 Jan 14.

Haaker J, Lonsdorf TB, Kalisch R. (2015). Effects of post-extinction l-DOPA administration on the spontaneous recovery and reinstatement of fear in a human fMRI study. Eur Neuropsychopharmacol., pii: S0924-977X(15)00234-5. doi: 10.1016/j.euroneuro.2015.07.016. [Epub ahead of print].

Lonsdorf TB, Haaker J, Schümann D, Sommer T, Bayer J, Brassen S, Bunzeck N, Gamer M, Kalisch R. (2015). Sex differences in conditioned stimulus discrimination during context-dependent fear learning and its retrieval in humans: the role of biological sex, contraceptives and menstrual cycle phases. J Psychiatry Neurosci., 40(4):140336. doi: 10.1503/jpn.140336.

Meyer B, Yuen KS, Ertl M, Polomac N, Mulert C, Büchel C, Kalisch R.(2015). Neural mechanisms of placebo anxiolysis. J Neurosci., 35(19):7365-73. doi: 10.1523/JNEUROSCI.4793-14.2015.

Kalisch R, Müller MB, Tüscher O (2014) Transdiagnostisch, multisystemisch, quantitativ: Einige grundsätzliche Überlegungen zu Strategien und Studiendesigns in der modernen Resilienzforschung. Persönlichkeitsstörungen: Theorie und Therapie, 18(4):203–214

Gröger A, Kolb R, Schäfer R, Klose U. Dopamine reduction in the substantia nigra of Parkinson’s disease patients confirmed by in vivo magnetic resonance spectroscopic imaging. PLoS One. 2014 Jan 8;9(1):e84081. doi: 10.1371/journal.pone.0084081. eCollection 2014.

Kalisch R, Gerlicher AM. (2014). Making a mountain out of a molehill: On the role of the rostral dorsal anterior cingulate and dorsomedial prefrontal cortex in conscious threat appraisal, catastrophizing, and worrying. Neurosci Biobehav Rev. 2014 Feb 10;42C:1-8. doi: 10.1016.

Haaker J, Lonsdorf TB, Raczka KA, Mechias ML, Gartmann N, Kalisch R. (2014). Higher anxiety and larger amygdala volumes in carriers of a TMEM132D risk variant for panic disorder. Transl Psychiatry. Feb 4;4:e357. doi: 10.1038

Lonsdorf TB, Haaker J, Kalisch R (2014). Long-term expression of human contextual fear and extinction memories involves amygdala, hippocampus and ventromedial prefrontal cortex: a reinstatement study in two independent samples. Soc Cogn Affect Neurosci. Mar 11. [Epub ahead of print]

Raes AK, De Houwer J, De Schryver M, Brass M, Kalisch R. (2014). Do CS-US Pairings Actually Matter? A Within-Subject Comparison of Instructed Fear Conditioning with and without Actual CS-US Pairings. PLoS One Jan 23;9(1):e84888. doi: 10.1371

Haaker J, Gaburro S, Sah A, Gartmann N, Lonsdorf TB, Meier K, Singewald N, Pape HC, Morellini F*, Kalisch R* (2013) Single dose of L-dopa makes extinction memories context-independent and prevents the return of fear. PNAS 110:E2428-36. * equal contribution

Menz MM, Rihm JS, Salari N, Born J, Kalisch R, Pape HC, Marshall L, Büchel C (2013) The role of sleep and sleep deprivation in consolidating fear memories. Neuroimage 75:87-96.

Lonsdorf TB, Haaker J, Fadai T, Kalisch R (2013) No evidence for enhanced extinction memory consolidation through noradrenergic reuptake inhibition-delayed memory test and reinstatement in human fMRI. Psychopharmacology[Epub ahead of print]

Haaker J, Lonsdorf TB, Thanellou A, Kalisch R (2013) Multimodal assessment of long-term memory recall and reinstatement in a combined cue and context fear conditioning and extinction paradigm in humans. PLoS One 8(10):e76179

 

The NIC supports

 

Zipp_SFB
Mainz Resilience Project (MARP) drz

News

02. November 2017
NIC meeting
Renee Visser (University Camebridge) presents her work on “Imaging the dynamic nature of emotional memory” in the NIC meeting on Thursday, November 2nd at 12am. ...more
19. October 2017
NIC meeting
Benjamin Meyer (NIC) will present his new study investigating  “The neural networks of instructed fear” in the NIC meeting on Thursday, October 19th at 12 in the seminar room....more
14. September 2017
NIC meeting
Christian Paret (Central Institute of Mental Health, Mannheim) will give a talk on “Real-time fMRI neurofeedback from the amygdala: Feasibility, clinical application and brain mechanisms” in the NIC meeting on Thursday, September 14th....more